ea0029p1203 | Obesity | ICEECE2012
Nishiyama M.
, Nakayama S.
, Okazaki M.
, Tsugita M.
, Taguchi T.
, Makino S.
, Okada Y.
, Tsuda M.
, Iwasaki Y.
, Terada Y.
Purpose: Glucocorticoid excess causes obesity and hyperphagia (e.g. Cushing syndrome), but the molecular mechanism of glucocorticoid-induced hyperphagia is not fully understood. To clarify this point, we investigated here the phenotype of leptin and Corticotropin-releasing hormone (CRH) double knockout mice (DKO).Methods: Leptin-deficient ob/ob mice were bred with CRH-deficient mice for generation of DKO mice. We examined body weight, food consumption an...